A Chimeric UDP-Glucose Pyrophosphorylase Produced by Protein Engineering Exhibits Sensitivity to Allosteric Regulators

A Chimeric UDP-Glucose Pyrophosphorylase Produced by Protein Engineering Exhibits Sensitivity to Allosteric Regulators

In bacteria, glycogen or oligosaccharide accumulation involves glucose-1-phosphate partitioning into either ADP-glucose (ADP-Glc) or UDP-Glc. Their respective synthesis is catalyzed by allosterically regulated ADP-Glc pyrophosphorylase (EC 2.7.7.27, ADP-Glc PPase) or unregulated UDP-Glc PPase (EC 2....

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Bibliographic Details
Main Authors: Matías D. Asención Diez, Ana C. Ebrecht, Lucila I. Martínez, Mabel C. Aleanzi, Sergio A. Guerrero, Miguel A. Ballícora, Alberto A. Iglesias
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:International Journal of Molecular Sciences
Subjects:
protein engineering
allosteric regulation
pyrophosphorylases evolution
UDP-glucose
ADP-glucose
Online Access:http://www.mdpi.com/1422-0067/14/5/9703

Internet

http://www.mdpi.com/1422-0067/14/5/9703

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