Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

Abstract Pediatric high grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPGs), are aggressive tumors with a dismal outcome. Radiotherapy (RT) is part of the standard of care of these tumors; however, radiotherapy only leads to a transient clinical improvement. Delta-24-RGD is a g...

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Bibliographic Details
Main Authors: Naiara Martinez-Velez, Miguel Marigil, Marc García-Moure, Marisol Gonzalez-Huarriz, Jose Javier Aristu, Luis-Isaac Ramos-García, Sonia Tejada, Ricardo Díez-Valle, Ana Patiño-García, Oren J. Becher, Candelaria Gomez-Manzano, Juan Fueyo, Marta M. Alonso
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Acta Neuropathologica Communications
Subjects:
pHGG
DIPG
Radiotherapy
Oncolytic virus
DNA damage
Immune response
Online Access:http://link.springer.com/article/10.1186/s40478-019-0714-6

Internet

http://link.springer.com/article/10.1186/s40478-019-0714-6

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