Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

This study evaluates the embryotoxicity of dithienylethene-modified peptides upon photoswitching, using 19 analogues based on the β-hairpin scaffold of the natural membranolytic peptide gramicidin S. We established an in vivo assay in two variations (with ex vivo and in situ photoisomerization), usi...

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Bibliographic Details
Main Authors: Sergii Afonin, Oleg Babii, Aline Reuter, Volker Middel, Masanari Takamiya, Uwe Strähle, Igor V. Komarov, Anne S. Ulrich
Format: Article
Language:English
Published: Beilstein-Institut 2020-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
diarylethene photoswitch
gramicidin s
membrane-active peptides
photopharmacology
zebrafish embryotoxicity model
Online Access:https://doi.org/10.3762/bjoc.16.6

Internet

https://doi.org/10.3762/bjoc.16.6

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