The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin

The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin

Summary: Oncogenic histone lysine-to-methionine mutations block the methylation of their corresponding lysine residues on wild-type histones. One attractive model is that these mutations sequester histone methyltransferases, but genome-wide studies show that mutant histones and histone methyltransfe...

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Bibliographic Details
Main Authors: Chun-Min Shan, Jin-Kwang Kim, Jiyong Wang, Kehan Bao, Yadong Sun, Huijie Chen, Jia-Xing Yue, Alessandro Stirpe, Zhiguo Zhang, Chao Lu, Thomas Schalch, Gianni Liti, Peter L. Nagy, Liang Tong, Feng Qiao, Songtao Jia
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004769

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http://www.sciencedirect.com/science/article/pii/S2211124721004769

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