Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

Abstract Background Long-term use of morphine induces analgesic tolerance, which limits its clinical efficacy. Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was important for morphine tolerance. In our...

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Bibliographic Details
Main Authors: Jie Qu, Xue-You Tao, Peng Teng, Yan Zhang, Ci-Liang Guo, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Liu
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Neuroinflammation
Subjects:
Morphine tolerance
HSP70
TLR4
KATP channel
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-017-0997-0

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http://link.springer.com/article/10.1186/s12974-017-0997-0

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