A series of N-terminal epitope tagged <it>Hdh</it> knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis

A series of N-terminal epitope tagged <it>Hdh</it> knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis

<p>Abstract</p> <p>Background</p> <p>Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease that is caused by the expansion of a polyglutamine (polyQ) stretch within Huntingtin (htt), the protein product of the HD gene. Although studies in vitro ha...

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Bibliographic Details
Main Authors: Zheng Shuqiu, Ghitani Nima, Blackburn Jessica S, Liu Jeh-Ping, Zeitlin Scott O
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Molecular Brain
Subjects:
Huntingtin
Epitope tag
Knock-in
Polyglutamine
Proline-rich region
Sequestration
Huntington’s disease
Online Access:http://www.molecularbrain.com/content/5/1/28

Internet

http://www.molecularbrain.com/content/5/1/28

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