Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells

Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells

Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E...

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Bibliographic Details
Main Authors: Vikas Duhan, Vishal Khairnar, Simo Kitanovski, Thamer A. Hamdan, Andrés D. Klein, Judith Lang, Murtaza Ali, Tom Adomati, Hilal Bhat, Sarah-Kim Friedrich, Fanghui Li, Philippe Krebs, Anthony H. Futerman, Marylyn M. Addo, Cornelia Hardt, Daniel Hoffmann, Philipp A. Lang, Karl S. Lang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
GWAS
genome wide association screen
Itgae
CD103
vesicular stomatitis virus
IFN-I
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.607889/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.607889/full

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