Trivalent adenovirus type 5 HIV recombinant vaccine primes for modest cytotoxic capacity that is greatest in humans with protective HLA class I alleles.

Trivalent adenovirus type 5 HIV recombinant vaccine primes for modest cytotoxic capacity that is greatest in humans with protective HLA class I alleles.

If future HIV vaccine design strategies are to succeed, improved understanding of the mechanisms underlying protection from infection or immune control over HIV replication remains essential. Increased cytotoxic capacity of HIV-specific CD8+ T-cells associated with efficient elimination of HIV-infec...

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Bibliographic Details
Main Authors: Stephen A Migueles, Julia E Rood, Amy M Berkley, Tiffany Guo, Daniel Mendoza, Andy Patamawenu, Claire W Hallahan, Nancy A Cogliano, Nicole Frahm, Ann Duerr, M Juliana McElrath, Mark Connors
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3044701?pdf=render

Internet

http://europepmc.org/articles/PMC3044701?pdf=render

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