Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice.

Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice.

The clinical uses of 2-chloro-2'-deoxyadenosine (2-CDA) or cladribine which was initially prescribed to patients with hematological and lymphoid cancers is now extended to treat patients with multiple sclerosis (MS). Previous data has shown that 2-CDA has high affinity to the brain and readily...

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Bibliographic Details
Main Authors: Crystal D Hayes, Debleena Dey, Juan Pablo Palavicini, Hongjie Wang, Wataru Araki, Madepalli K Lakshmana
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3463612?pdf=render

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http://europepmc.org/articles/PMC3463612?pdf=render

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