Direct but no transgenerational effects of decitabine and vorinostat on male fertility.

Establishment and maintenance of the correct epigenetic code is essential for a plethora of physiological pathways and disturbed epigenetic patterns can provoke severe consequences, e.g. tumour formation. In recent years, epigenetic drugs altering the epigenome of tumours actively have been develope...

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Main Authors: Ruth Kläver, Victoria Sánchez, Oliver S Damm, Klaus Redmann, Elisabeth Lahrmann, Reinhild Sandhowe-Klaverkamp, Christian Rohde, Joachim Wistuba, Jens Ehmcke, Stefan Schlatt, Jörg Gromoll
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4334483?pdf=render