Instant activation of TRP channels by NH4+ promotes neuronal bursting and glutamate spikes in CA1 neurons

Ammonia (NH4+) is a by-product of cell metabolism and may elicit subcellular effects with specific physiological responses. Chronic effects have been implicated in several neurological diseases and attributed to persistent elevation in blood ammonia levels transferred to the brain. In previous studi...

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Bibliographic Details
Main Authors: Saju Balakrishnan, Sergej L. Mironov
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Current Research in Physiology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2665944120300079