CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

Targeting translation initiation is an emerging anti-neoplastic strategy that capitalizes on de-regulated upstream MAPK and PI3K-mTOR signaling pathways in cancers. A key regulator of translation that controls ribosome recruitment flux is eukaryotic initiation factor (eIF) 4F, a hetero-trimeric comp...

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Bibliographic Details
Main Authors: Jennifer Chu, Gabriela Galicia-Vázquez, Regina Cencic, John R. Mills, Alexandra Katigbak, John A. Porco Jr., Jerry Pelletier
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Subjects:
rocaglates
eIF4A
translational control
chemical biology
CRISPR/Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716305587

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http://www.sciencedirect.com/science/article/pii/S2211124716305587

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