Melanoma and the Unfolded Protein Response

The UPR (unfolded protein response) has been identified as a key factor in the progression and metastasis of cancers, notably melanoma. Several mediators of the UPR are upregulated in cancers, e.g., high levels of GRP78 (glucose-regulator protein 78 kDa) correlate with progression and poor outcome i...

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Bibliographic Details
Main Authors: Erin K. Sykes, Swetlana Mactier, Richard I. Christopherson
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Cancers
Subjects:
UPR
Online Access:http://www.mdpi.com/2072-6694/8/3/30