RNA Polymerase II cluster dynamics predict mRNA output in living cells

RNA Polymerase II cluster dynamics predict mRNA output in living cells

Protein clustering is a hallmark of genome regulation in mammalian cells. However, the dynamic molecular processes involved make it difficult to correlate clustering with functional consequences in vivo. We developed a live-cell super-resolution approach to uncover the correlation between mRNA synth...

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Bibliographic Details
Main Authors: Won-Ki Cho, Namrata Jayanth, Brian P English, Takuma Inoue, J Owen Andrews, William Conway, Jonathan B Grimm, Jan-Hendrik Spille, Luke D Lavis, Timothée Lionnet, Ibrahim I Cisse
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
transcription
RNA Polymerase II
mRNA
bursting
gene expression
clustering
Online Access:https://elifesciences.org/articles/13617

Internet

https://elifesciences.org/articles/13617

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