Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes

Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes

Abstract Background The poor response to current PD-1/PD-L1 inhibitors in lung cancer patients requires development of novel immunotargets. Immunoglobulin-like transcript (ILT)4 is an immunosuppressive molecule mainly expressed in myeloid innate cells. Recent studies showed that ILT4 was highly expr...

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Bibliographic Details
Main Authors: Qing Li, Juan Li, Shuyun Wang, Jingnan Wang, Xiaozheng Chen, Dongmei Zhou, Yuying Fang, Aiqin Gao, Yuping Sun
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Biomarker Research
Subjects:
Immunoglobulin-like transcript 4
Lung adenocarcinoma
T cell subset
Immunosuppression
Online Access:http://link.springer.com/article/10.1186/s40364-020-00191-7

Internet

http://link.springer.com/article/10.1186/s40364-020-00191-7

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