Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages

Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages

Foam cells formed from receptor-mediated uptake of lipoprotein cholesterol by macrophages in the arterial intima are critical in the initiation, progression, and stability of atherosclerotic lesions. Macrophages accumulate cholesterol when conditions favor esterification by acyl-CoA:cholesterol acyl...

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Bibliographic Details
Main Authors: Jean-Louis Escary, Henry A. Choy, Karen Reue, Xu-Ping Wang, Lawrence W. Castellani, Christopher K. Glass, Aldons J. Lusis, Michael C. Schotz
Format: Article
Language:English
Published: Elsevier 1999-03-01
Series:Journal of Lipid Research
Subjects:
cholesteryl-ester hydrolysis
acyl-CoA:cholesterol acyltransferase
foam cells
aortic lesions
transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520324433

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http://www.sciencedirect.com/science/article/pii/S0022227520324433

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