Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects

Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects

A series of new fluoroquinazolinone 6–8 and 10a–g derivatives was designed, prepared and screened for their in vitro cytotoxic activity against human cancer cell lines MCF-7 and MDA-MBA-231. Compounds 6 (IC50 = 0.35 ± 0.01 µM), 10f (IC50 = 0.71 ± 0...

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Bibliographic Details
Main Authors: Mohamed F. Zayed, Sahar Ahmed, Saleh Ihmaid, Hany E. A. Ahmed, Heba S. Rateb, Sabrin R. M. Ibrahim
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
design
fluoroquinazolinone
cytotoxicity
EGFR kinase
tubulin inhibitors
Online Access:http://www.mdpi.com/1422-0067/19/6/1731

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http://www.mdpi.com/1422-0067/19/6/1731

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