Endocervical Regulatory T Cells Are Associated With Decreased Genital Inflammation and Lower HIV Target Cell Abundance

Endocervical Regulatory T Cells Are Associated With Decreased Genital Inflammation and Lower HIV Target Cell Abundance

Regulatory T cells (Tregs) play important roles in tissue homeostasis, but few studies have investigated tissue Tregs in the context of genital inflammation, HIV target cell density, and vaginal microbiota in humans. In women from Nairobi (n=64), the proportion of CD4+ CD25+ CD127low Tregs in the en...

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Bibliographic Details
Main Authors: Aloysious Ssemaganda, Francois Cholette, Michelle Perner, Cheli Kambaran, Wendy Adhiambo, Peter M. Wambugu, Henok Gebrebrhan, Amy Lee, Faisal Nuhu, Ruth S. Mwatelah, Naima Jahan, Tosin E. Omole, Tabitha Wanjiru, Apollo Gitau, Joshua Kimani, Lyle R. McKinnon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells
female genital tract
HIV
inflammation
vaginal microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.726472/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.726472/full

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