Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney cancer

Loss of Von Hippel‐Lindau in renal carcinoma cells results in upregulation of the activity of hypoxia‐inducible factor (HIF‐α), a major transcription factor involved in kidney cancer. Rapamycin as mammalian target of rapamycin inhibitor and 5‐aminoimidazole‐4‐carboxamide‐riboside (AICAR) as AMPK act...

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Bibliographic Details
Main Authors: Sitai Liang, Edward A. Medina, Boajie Li, Samy L. Habib
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:Molecular Oncology
Subjects:
Online Access:https://doi.org/10.1002/1878-0261.12370