Sanguisorbae Radix Suppresses Colorectal Tumor Growth Through PD-1/PD-L1 Blockade and Synergistic Effect With Pembrolizumab in a Humanized PD-L1-Expressing Colorectal Cancer Mouse Model

Sanguisorbae Radix Suppresses Colorectal Tumor Growth Through PD-1/PD-L1 Blockade and Synergistic Effect With Pembrolizumab in a Humanized PD-L1-Expressing Colorectal Cancer Mouse Model

Immune checkpoints such as programmed death-1 (PD-1) have been proven as antitumor targets by enhancing cytotoxic T cell activity. All immune checkpoint blockades are antibody therapeutics that have large size and high affinity, as well as known immune-related side effects and low responses. To over...

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Bibliographic Details
Main Authors: Eun-Ji Lee, Ji Hye Kim, Tae In Kim, Yeon-Ji Kim, Malk Eun Pak, Chang Hyun Jeon, Yeo Jin Park, Wei Li, Young Soo Kim, Jang-Gi Choi, Hwan-Suck Chung
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
PD-1
PD-L1
Sanguisorbae Radix
cancer immunology
humanized PD-1 mice
tumor-infiltrating CD8+ T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.737076/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.737076/full

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