Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients

Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients

Abstract Background MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases. Overexpressed miRNAs play an important role in ALS; however, the pathogenic mechanisms of deregulated miRNAs are...

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Bibliographic Details
Main Authors: Ki Yoon Kim, Yu Ri Kim, Kyung Won Choi, Mijung Lee, Somyung Lee, Wooseok Im, Je-Young Shin, Jin Young Kim, Yoon Ho Hong, Manho Kim, Jong-Il Kim, Jung-Joon Sung
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Translational Neurodegeneration
Subjects:
miRNAs
Hif1α
Mef2c
Mctp1 and Rarb
Online Access:http://link.springer.com/article/10.1186/s40035-020-00203-4

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http://link.springer.com/article/10.1186/s40035-020-00203-4

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