A functional variant in ERAP1 predisposes to multiple sclerosis.

A functional variant in ERAP1 predisposes to multiple sclerosis.

The ERAP1 gene encodes an aminopeptidase involved in antigen processing. A functional polymorphism in the gene (rs30187, Arg528Lys) associates with susceptibility to ankylosying spondylitis (AS), whereas a SNP in the interacting ERAP2 gene increases susceptibility to another inflammatory autoimmune...

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Main Authors: Franca Rosa Guerini, Rachele Cagliani, Diego Forni, Cristina Agliardi, Domenico Caputo, Andrea Cassinotti, Daniela Galimberti, Chiara Fenoglio, Mara Biasin, Rosanna Asselta, Elio Scarpini, Giacomo P Comi, Nereo Bresolin, Mario Clerici, Manuela Sironi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3257233?pdf=render

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http://europepmc.org/articles/PMC3257233?pdf=render

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