DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency

DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency

Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target loci. Here, we demonstrate that 3D genome orga...

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Bibliographic Details
Main Authors: Katy McLaughlin, Ilya M. Flyamer, John P. Thomson, Heidi K. Mjoseng, Ruchi Shukla, Iain Williamson, Graeme R. Grimes, Robert S. Illingworth, Ian R. Adams, Sari Pennings, Richard R. Meehan, Wendy A. Bickmore
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719313312

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http://www.sciencedirect.com/science/article/pii/S2211124719313312

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