DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency
Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target loci. Here, we demonstrate that 3D genome orga...
Main Authors: | Katy McLaughlin, Ilya M. Flyamer, John P. Thomson, Heidi K. Mjoseng, Ruchi Shukla, Iain Williamson, Graeme R. Grimes, Robert S. Illingworth, Ian R. Adams, Sari Pennings, Richard R. Meehan, Wendy A. Bickmore |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-11-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719313312 |
Similar Items
-
Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
by: Donnchadh S. Dunican, et al.
Published: (2020-03-01) -
Polycomb enables primitive endoderm lineage priming in embryonic stem cells
by: Robert S Illingworth, et al.
Published: (2016-10-01) -
Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins
by: Margaret E. McLaughlin-Drubin, et al.
Published: (2013-05-01) -
Resetting Human Naïve Pluripotency
by: Jifang Xiao, et al.
Published: (2016-08-01) -
Resetting Human Naïve Pluripotency
by: Jifang Xiao, et al.
Published: (2016-01-01)