Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice.

Catch-up growth after insults to growing organs is paramount to achieving robust body proportions. In fly larvae, injury to individual tissues is followed by local and systemic compensatory mechanisms that allow the damaged tissue to regain normal proportions with other tissues. In vertebrates, loca...

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Bibliographic Details
Main Authors: Alberto Roselló-Díez, Linda Madisen, Sébastien Bastide, Hongkui Zeng, Alexandra L Joyner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2005086