Late airway obstruction and neutrophil infiltration in sensitized mice after antigen provocation were suppressed by selective and non-selective phosphodiesterase inhibitors

Late airway obstruction and neutrophil infiltration in sensitized mice after antigen provocation were suppressed by selective and non-selective phosphodiesterase inhibitors

Suppression of antigen-induced late airway obstruction associated with neutrophilic inflammation by selective and non-selective phosphodiesterase (PDE) inhibitors was investigated in mice. Respiratory resistance (Rrs) increased in sensitized BDF1 mice 4-6 h after antigen provocation, whereas no obvi...

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Bibliographic Details
Main Authors: Osamu Kaminuma, Shinya Murakami, Matsunobu Suko, Hideo Kikkawa, Shigeki Matsubara, Wataru Toriumi, Katsuo Ikezawa, Hirokazu Okudaira, Koji Ito
Format: Article
Language:English
Published: Elsevier 1997-01-01
Series:Allergology International
Subjects:
airway inflammation
airway obstruction
mouse
neutrophil
phosphodiesterase inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015315860

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http://www.sciencedirect.com/science/article/pii/S1323893015315860

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