Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

Activation triggers the exchange of subunits in Ca2+/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We show that the human CaMKII holoenzyme exists in d...

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Bibliographic Details
Main Authors: Moitrayee Bhattacharyya, Margaret M Stratton, Catherine C Going, Ethan D McSpadden, Yongjian Huang, Anna C Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine L Gee, Tiago Barros, Howard Schulman, Evan R Williams, John Kuriyan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
subunit exchange
structural transition
kinase activation
Ca2+/CaM stimulus
Online Access:https://elifesciences.org/articles/13405

Internet

https://elifesciences.org/articles/13405

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