The β2-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy

The β2-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy

L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cavα1 pore-forming subunit and the accessory subunits Cavβ, Cavα2δ, and Cavγ. Cavβ is a cytosolic protein that regulates channel trafficking and activity, but it also exerts...

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Bibliographic Details
Main Authors: Simone Pickel, Yiliam Cruz-Garcia, Sandra Bandleon, Katalin Barkovits, Cornelia Heindl, Katharina Völker, Marco Abeßer, Kathy Pfeiffer, Alice Schaaf, Katrin Marcus, Petra Eder-Negrin, Michaela Kuhn, Erick Miranda-Laferte
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
L-type voltage-gated calcium channels
cardiac hypertrophy
calpain
cardiomyocytes
calpastatin
Cavβ2-subunit
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.704657/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.704657/full

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