A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif

A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif

Pit2 is a secreted Ustilago maydis effector that contributes to corn smut disease by inhibiting papain-like cysteine proteases (PLCPs) in maize. Here Misas Villamil et al. show that Pit2 mimics PLCP substrates, and is cleaved to release a peptide that blocks PLCP activity and represses host immunity...

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Main Authors: Johana C. Misas Villamil, André N. Mueller, Fatih Demir, Ute Meyer, Bilal Ökmen, Jan Schulze Hüynck, Marlen Breuer, Helen Dauben, Joe Win, Pitter F. Huesgen, Gunther Doehlemann
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09472-8
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spelling doaj-495eae392b784d318ad6d240dd7dad052021-05-11T11:44:45ZengNature Publishing GroupNature Communications2041-17232019-04-0110111510.1038/s41467-019-09472-8A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motifJohana C. Misas Villamil0André N. Mueller1Fatih Demir2Ute Meyer3Bilal Ökmen4Jan Schulze Hüynck5Marlen Breuer6Helen Dauben7Joe Win8Pitter F. Huesgen9Gunther Doehlemann10Botanical Institute and Cluster of Excellence on Plant Sciences, University of CologneMax Planck Institute for Terrestrial MicrobiologyCentral Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum JülichBotanical Institute and Cluster of Excellence on Plant Sciences, University of CologneBotanical Institute and Cluster of Excellence on Plant Sciences, University of CologneBotanical Institute and Cluster of Excellence on Plant Sciences, University of CologneMax Planck Institute for Terrestrial MicrobiologyBotanical Institute and Cluster of Excellence on Plant Sciences, University of CologneThe Sainsbury Laboratory, Norwich Research ParkCentral Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum JülichBotanical Institute and Cluster of Excellence on Plant Sciences, University of ColognePit2 is a secreted Ustilago maydis effector that contributes to corn smut disease by inhibiting papain-like cysteine proteases (PLCPs) in maize. Here Misas Villamil et al. show that Pit2 mimics PLCP substrates, and is cleaved to release a peptide that blocks PLCP activity and represses host immunity.https://doi.org/10.1038/s41467-019-09472-8
collection DOAJ
language English
format Article
sources DOAJ
author Johana C. Misas Villamil
André N. Mueller
Fatih Demir
Ute Meyer
Bilal Ökmen
Jan Schulze Hüynck
Marlen Breuer
Helen Dauben
Joe Win
Pitter F. Huesgen
Gunther Doehlemann
spellingShingle Johana C. Misas Villamil
André N. Mueller
Fatih Demir
Ute Meyer
Bilal Ökmen
Jan Schulze Hüynck
Marlen Breuer
Helen Dauben
Joe Win
Pitter F. Huesgen
Gunther Doehlemann
A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
Nature Communications
author_facet Johana C. Misas Villamil
André N. Mueller
Fatih Demir
Ute Meyer
Bilal Ökmen
Jan Schulze Hüynck
Marlen Breuer
Helen Dauben
Joe Win
Pitter F. Huesgen
Gunther Doehlemann
author_sort Johana C. Misas Villamil
title A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
title_short A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
title_full A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
title_fullStr A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
title_full_unstemmed A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
title_sort fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-04-01
description Pit2 is a secreted Ustilago maydis effector that contributes to corn smut disease by inhibiting papain-like cysteine proteases (PLCPs) in maize. Here Misas Villamil et al. show that Pit2 mimics PLCP substrates, and is cleaved to release a peptide that blocks PLCP activity and represses host immunity.
url https://doi.org/10.1038/s41467-019-09472-8
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