Multi-Omics Analysis of Diabetic Heart Disease in the <i>db/db</i> Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene

Multi-Omics Analysis of Diabetic Heart Disease in the <i>db/db</i> Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene

Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the adverse influence of diabetes on the heart, and the transfer of a longevity-associated variant (LAV) of the human <i>BPIFB4</i>...

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Bibliographic Details
Main Authors: Ashton Faulkner, Zexu Dang, Elisa Avolio, Anita C Thomas, Thomas Batstone, Gavin R Lloyd, Ralf JM Weber, Lukáš Najdekr, Andris Jankevics, Warwick B Dunn, Gaia Spinetti, Carmine Vecchione, Annibale A Puca, Paolo Madeddu
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
cardiomyopathy
type-2 diabetes
longevity
gene therapy
BPIFB4
Online Access:https://www.mdpi.com/2073-4409/9/5/1283

Internet

https://www.mdpi.com/2073-4409/9/5/1283

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