Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

Summary: Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is highly localized to the liver and pancreatic α cells. Although DBP serum levels, gene polymorphisms, and autoantigens have all been...

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Bibliographic Details
Main Authors: Katrina Viloria, Daniela Nasteska, Linford J.B. Briant, Silke Heising, Dean P. Larner, Nicholas H.F. Fine, Fiona B. Ashford, Gabriela da Silva Xavier, Maria Jiménez Ramos, Annie Hasib, Federica Cuozzo, Jocelyn E. Manning Fox, Patrick E. MacDonald, Ildem Akerman, Gareth G. Lavery, Christine Flaxman, Noel G. Morgan, Sarah J. Richardson, Martin Hewison, David J. Hodson
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
α cell
glucagon
GC-globulin
vitamin D
vitamin-D-binding protein
type 1 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307415

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http://www.sciencedirect.com/science/article/pii/S2211124720307415

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