Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer

Abstract Background Invasive lobular breast carcinoma (ILC) is a histological subtype of breast cancer that is characterized by loss of E-cadherin and high expression of estrogen receptor alpha (ERα). In many cases, ILC is effectively treated with adjuvant aromatase inhibitors (AIs); however, acquir...

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Bibliographic Details
Main Authors: Tian Du, Matthew J. Sikora, Kevin M. Levine, Nilgun Tasdemir, Rebecca B. Riggins, Stacy G. Wendell, Bennett Van Houten, Steffi Oesterreich
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Breast Cancer Research
Subjects:
Invasive lobular breast
Endocrine resistance
LTED
SREBP1
Fatty acid
Cholesterol
Online Access:http://link.springer.com/article/10.1186/s13058-018-1041-8

Internet

http://link.springer.com/article/10.1186/s13058-018-1041-8

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