Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells

Abstract Background Aurora kinase A (AURKA) has been implicated in the regulation of cell cycle progression, mitosis and a key number of oncogenic signaling pathways in various malignancies including neuroblastoma. Small molecule inhibitors of AURKA have shown potential, but still not as good as exp...

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Bibliographic Details
Main Authors: Yan Yang, Lili Ding, Qi Zhou, Li Fen, Yuhua Cao, Junjie Sun, Xuefeng Zhou, Aiguo Liu
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Cancer Cell International
Subjects:
MLN8237
Neuroblastoma
Aurora kinase A
Small interfering RNA
Cellular senescence
Online Access:https://doi.org/10.1186/s12935-019-1072-y

Internet

https://doi.org/10.1186/s12935-019-1072-y

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