A composition-dependent molecular clutch between T cell signaling condensates and actin

A composition-dependent molecular clutch between T cell signaling condensates and actin

During T cell activation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP. These condensates move radially at the IS, traversing successive radially-oriented and concentric actin networks. To under...

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Bibliographic Details
Main Authors: Jonathon A Ditlev, Anthony R Vega, Darius Vasco Köster, Xiaolei Su, Tomomi Tani, Ashley M Lakoduk, Ronald D Vale, Satyajit Mayor, Khuloud Jaqaman, Michael K Rosen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
biomolecular condensate
T cell signaling
actin cytoskeleton
compositional control
biochemical reconstitution
LAT microclusters
Online Access:https://elifesciences.org/articles/42695

Internet

https://elifesciences.org/articles/42695

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