Effects of Pin1 loss in HdhQ111 knock-in mice

Effects of Pin1 loss in HdhQ111 knock-in mice

Huntington’s disease (HD) is a fatal, dominantly inherited, neurodegenerative disorder due to a pathological expansion of the CAG repeat in the coding region of the HTT gene. In the quest for understanding the molecular basis of neurodegeneration, we have previously demonstrated that the prolyl isom...

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Bibliographic Details
Main Authors: Elena eAgostoni, Silvia eMichelazzi, Marta eMaurutto, Alisia eCarnemolla, Yari eCiani, Paolo eVatta, Paola eRoncaglia, Silvia eZucchelli, Giampiero eLeanza, Fiamma eMantovani, Stefano eGustincich, Claudio eSantoro, Silvano ePiazza, Giannino eDel Sal, Francesca ePersichetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Gliosis
Huntington's disease
DNA damage response
Pin1
Neuronal intranuclear inclusions
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00110/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00110/full

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