Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures

Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures

sCJD occurrence is currently assumed to result from spontaneous and stochastic formation of a misfolded PrP nucleus in the brains of affected patients. This original nucleus then recruits and converts nascent PrPC into PrPSc, leading to the propagation of prions in the patient’s brain. Our study dem...

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Bibliographic Details
Main Authors: Hervé Cassard, Alvina Huor, Juan-Carlos Espinosa, Jean-Yves Douet, Severine Lugan, Naima Aron, Didier Vilette, Marie-Bernadette Delisle, Alba Marín-Moreno, Patrice Peran, Vincent Beringue, Juan Maria Torres, James W. Ironside, Olivier Andreoletti
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
prion
sporadic creutzfeldt-jakob disease
strain diversity
evolution
diversity
prions
scjd
strains
Online Access:https://doi.org/10.1128/mBio.00393-20

Internet

https://doi.org/10.1128/mBio.00393-20

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