Digital immunoassay for biomarker concentration quantification using solid-state nanopores

The concentration of a biomarker in solution can be determined by counting single molecules. Here the authors report a digital immunoassay scheme with solid-state nanopore readout to quantify a target protein and use this to measure thyroid-stimulating hormone from human serum.

Bibliographic Details
Main Authors: Liqun He, Daniel R. Tessier, Kyle Briggs, Matthaios Tsangaris, Martin Charron, Erin M. McConnell, Dmytro Lomovtsev, Vincent Tabard-Cossa
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25566-8