Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway.

Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway.

Sex reversal can occur in XY humans with only a single functional WT1 or SF1 allele or a duplication of the chromosome region containing WNT4. In contrast, XY mice with only a single functional Wt1, Sf1, or Wnt4 allele, or mice that over-express Wnt4 from a transgene, reportedly are not sex-reversed...

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Bibliographic Details
Main Authors: Stephanie M Correa, Linda L Washburn, Ravi S Kahlon, Michelle C Musson, Gerrit J Bouma, Eva M Eicher, Kenneth H Albrecht
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3320579?pdf=render

Internet

http://europepmc.org/articles/PMC3320579?pdf=render

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