Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation

Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation

Early radiokinetic studies revealed that the classical metabolic defect in patients with familial hypercholesterolemia (FH) is hypocatabolism of LDL due to decreased LDL receptor activity. However, recent studies have suggested that hepatic oversecretion of apolipoprotein B-100 (apoB-100)-containing...

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Bibliographic Details
Main Authors: André J. Tremblay, Benoît Lamarche, Isabelle L. Ruel, Jean-Charles Hogue, Jean Bergeron, Claude Gagné, Patrick Couture
Format: Article
Language:English
Published: Elsevier 2004-05-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein B-100
gas chromatography/mass spectrometry
kinetic
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520318265

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http://www.sciencedirect.com/science/article/pii/S0022227520318265

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