DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention

DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention

The present study is a pursuit to define implications of dual cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention. The monotherapy and combination therapy of zaltoprofen (COX-2 inhibitor) and zileuton (5-LOX inhibi...

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Bibliographic Details
Main Authors: Swetlana Gautam, Atul K. Rawat, Shreesh R. Sammi, Subhadeep Roy, Manjari Singh, Uma Devi, Rajnish K. Yadav, Lakhveer Singh, Jitendra K. Rawat, Mohd N. Ansari, Abdulaziz S. Saeedan, Dinesh Kumar, Rakesh Pandey, Gaurav Kaithwas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
DuCLOX-2/5 inhibition
angiogenesis
apoptosis
cyclooxygenase
lipoxygenase
NMR
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00314/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00314/full

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