Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

Rabex-5 and Rabaptin-5 function together to activate Rab5 and further promote early endosomal fusion in endocytosis. The Rabex-5 GEF activity is autoinhibited by the Rabex-5 CC domain (Rabex-5CC) and activated by the Rabaptin-5 C2-1 domain (Rabaptin-5C21) with yet unknown mechanism. We report here t...

Full description

Bibliographic Details
Main Authors: Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-06-01
Series:eLife
Subjects:
crystal structure
Rab5
rabex-5
Rabaptin-5
GEF activity
molecular mechanism
Online Access:https://elifesciences.org/articles/02687

Internet

https://elifesciences.org/articles/02687

Similar Items