Plasma biomarkers for monitoring brain pathophysiology in FMR1 premutation carriers

Plasma biomarkers for monitoring brain pathophysiology in FMR1 premutation carriers

Premutation carriers have a 55-200 CGG expansion in the fragile X mental retardation 1 (FMR1) gene. Currently, 1.5 million individuals are affected in the United States, and carriers are at risk of developing the late-onset neurodegenerative disorder Fragile X-associated tremor ataxia syndrome (FXTA...

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Bibliographic Details
Main Authors: Cecilia Giulivi, Eleonora Napoli, Flora Tassone, Julian Halmai, Randi Hagerman
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Fragile X Syndrome
Metabolomics
neurodegeneration
Mitochondrial dysfunction
Trinucleotide repeat diseases
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00071/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00071/full

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