Cochlear Gene Therapy for Sensorineural Hearing Loss: Current Status and Major Remaining Hurdles for Translational Success

Cochlear Gene Therapy for Sensorineural Hearing Loss: Current Status and Major Remaining Hurdles for Translational Success

Sensorineural hearing loss (SNHL) affects millions of people. Genetic mutations play a large and direct role in both congenital and late-onset cases of SNHL (e.g., age-dependent hearing loss, ADHL). Although hearing aids can help moderate to severe hearing loss the only effective treatment for deaf...

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Bibliographic Details
Main Authors: Wenjuan Zhang, Sun Myoung Kim, Wenwen Wang, Cuiyuan Cai, Yong Feng, Weijia Kong, Xi Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cochlear gene therapy
review
viral-mediated gene expression
preclinical trials
hearing restoration
sensorineural hearing loss
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00221/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00221/full

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