Case Report: Coexistence of Alzheimer-Type Neuropathology in Fragile X-Associated Tremor Ataxia Syndrome

Case Report: Coexistence of Alzheimer-Type Neuropathology in Fragile X-Associated Tremor Ataxia Syndrome

This case documents the co-occurrence of the fragile X-associated tremor ataxia syndrome (FXTAS) and Alzheimer-type neuropathology in a 71-year-old premutation carrier with 85 CGG repeats in the fragile X mental retardation 1 (FMR1) gene, in addition to an apolipoprotein E (APOE) ε4 allele. FXTAS an...

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Bibliographic Details
Main Authors: Maria Jimena Salcedo-Arellano, Desiree Sanchez, Jun Yi Wang, Yingratana A. McLennan, Courtney Jessica Clark, Pablo Juarez, Andrea Schneider, Flora Tassone, Randi J. Hagerman, Verónica Martínez-Cerdeño
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
FXTAS
Alzheimer-type dementia
FMR1 gene
CGG expansion
APOE ε4 allele
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.720253/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.720253/full

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