Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

Excessive glucose production by the liver contributes to poor blood glucose control in type 2 diabetes. Here the authors report that the liver kinase B1 (Lkb1) suppresses amino acid driven postprandial glucose production in the liver through the aminotransferase Agxt.

Bibliographic Details
Main Authors: Pierre-Alexandre Just, Sara Charawi, Raphaël G. P. Denis, Mathilde Savall, Massiré Traore, Marc Foretz, Sultan Bastu, Salimata Magassa, Nadia Senni, Pierre Sohier, Maud Wursmer, Mireille Vasseur-Cognet, Alain Schmitt, Morgane Le Gall, Marjorie Leduc, François Guillonneau, Jean-Pascal De Bandt, Patrick Mayeux, Béatrice Romagnolo, Serge Luquet, Pascale Bossard, Christine Perret
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19490-6

Internet

https://doi.org/10.1038/s41467-020-19490-6

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