Narrowing the field: cancer-specific promoters for mitochondrially-targeted p53-BH3 fusion gene therapy in ovarian cancer

Narrowing the field: cancer-specific promoters for mitochondrially-targeted p53-BH3 fusion gene therapy in ovarian cancer

Abstract Background Despite years of research, the treatment options and mortality rate for ovarian cancer remain relatively stagnant. Resistance to chemotherapy and high heterogeneity in mutations contribute to ovarian cancer’s lethality, including many mutations in tumor suppressor p53. Though wil...

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Bibliographic Details
Main Authors: Katherine Redd Bowman, Ji Hoon Kim, Carol S. Lim
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
p53
Gene therapy
Cancer-specific promoters
Mitochondrial targeting
hTERT
Online Access:http://link.springer.com/article/10.1186/s13048-019-0514-4

Internet

http://link.springer.com/article/10.1186/s13048-019-0514-4

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