Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies.

Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies.

The HIV-1 gp41 envelope (Env) membrane proximal external region (MPER) is an important vaccine target that in rare subjects can elicit neutralizing antibodies. One mechanism proposed for rarity of MPER neutralizing antibody generation is lack of reverted unmutated ancestor (putative naive B cell rec...

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Bibliographic Details
Main Authors: Ben-Jiang Ma, S Munir Alam, Eden P Go, Xiaozhi Lu, Heather Desaire, Georgia D Tomaras, Cindy Bowman, Laura L Sutherland, Richard M Scearce, Sampa Santra, Norman L Letvin, Thomas B Kepler, Hua-Xin Liao, Barton F Haynes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3164629?pdf=render

Internet

http://europepmc.org/articles/PMC3164629?pdf=render

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