Drug Screening, Oral Bioavailability and Regulatory Aspects: A Need for Human Organoids

Drug Screening, Oral Bioavailability and Regulatory Aspects: A Need for Human Organoids

The intestinal epithelium critically contributes to oral bioavailability of drugs by constituting an important site for drug absorption and metabolism. In particular, intestinal epithelial cells (IEC) actively serve as gatekeepers of drug and nutrient availability. IECs’ transport processes and meta...

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Bibliographic Details
Main Authors: Tamara Zietek, Wolfgang A. D. Boomgaarden, Eva Rath
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
intestinal organoids
regulatory aspects
nutrient absorption
drug uptake
non-animal models
3R
Online Access:https://www.mdpi.com/1999-4923/13/8/1280

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https://www.mdpi.com/1999-4923/13/8/1280

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