Transforming growth factor-β, MAPK and Wnt signaling interactions in colorectal cancer

Transforming growth factor-β, MAPK and Wnt signaling interactions in colorectal cancer

In non-cancerous cells, transforming growth factor-β (TGFβ) regulates cellular responses primarily through Smad signaling. However, during cancer progression (including colorectal) TGFβ promotes tumoral growth via Smad-independent mechanisms and is involved in crosstalk with various pathways like th...

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Bibliographic Details
Main Authors: Harish R. Cheruku, Abidali Mohamedali, David I. Cantor, Sock Hwee Tan, Edouard C. Nice, Mark S. Baker
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:EuPA Open Proteomics
Subjects:
Transforming growth factor-β
Colorectal cancer
TGFβ crosstalk
MAPK pathways
Wnt
Online Access:http://www.sciencedirect.com/science/article/pii/S2212968515300064

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http://www.sciencedirect.com/science/article/pii/S2212968515300064

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