Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State Through Inhibition of DNA Double Strand Break Repair

Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State Through Inhibition of DNA Double Strand Break Repair

(1) <i>Background:</i> The combination of the first-generation antiandrogens and radiotherapy (RT) has been studied extensively in the clinical setting of prostate cancer (PCa). Here, we evaluated the potential radiosensitizing effect of the second-generation antiandrogens abiraterone ac...

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Bibliographic Details
Main Authors: Mohamed E. Elsesy, Su Jung Oh-Hohenhorst, Anastassia Löser, Christoph Oing, Sally Mutiara, Sabrina Köcher, Stefanie Meien, Alexandra Zielinski, Susanne Burdak-Rothkamm, Derya Tilki, Hartwig Huland, Rudolf Schwarz, Cordula Petersen, Carsten Bokemeyer, Kai Rothkamm, Wael Y. Mansour
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
abiraterone acetate
apalutamide
enzalutamide
DNA double strand break repair
prostate cancer
radiosensitization
Online Access:https://www.mdpi.com/2072-6694/12/9/2467

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https://www.mdpi.com/2072-6694/12/9/2467

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